Lipotropic Substances *
نویسنده
چکیده
Lipotropic action of choline In 1924 Allan, Bowie, Macleod, and Robinson' reported that depancreatized dogs receiving adequate amounts of insulin and maintained on a diet of lean meat, sucrose, and bone ash did not survive for periods of longer than a few months. They also observed that symptoms of failure of liver function due to fat infiltration of the liver found in such animals could be prevented by adding raw pancreas to the diet. They suggested, therefore, that the pancreas might possibly produce an internal secretion necessary for the physiological integrity of the liver. In 1930 and 1931 Hershey56 and Hershey and Soskin57 found that crude egg-yolk lecithin could successfully replace raw pancreas in the diet of the depancreatized dog. Attention was temporarily withdrawn from the study of the fatty liver of the depancreatized dog by the discovery by Best et al."3 that the development of fatty livers in rats fed on a high fat diet could be prevented by the addition of lecithin to the diet. The application of this relatively simple type of experiment, that is, the use of rats fed on a diet of mixed grain and containing 40% beef fat, in place of the use of the depancreatized dog, led to rapid progress in the field. The first step in the development was made by Best and Huntsman"4 when they found that choline was the active agent in lecithin which prevented the accumulation of liver fat. Subsequent work by Best, Channon, and Ridout" on fractionation of the liver fat revealed that the fatty liver caused by feeding diets high in fat was occasioned entirely by an increase in the neutral fat fraction with no effect on the cholesterol or phospholipid fractions, and they also obtained confirmation of the action of choline in preventing such
منابع مشابه
Dose-response curves in the estimation of potency of lipotropic agents.
In the 18 years which have elapsed since the lipotropic activity of choline was discovered, four other naturally occurring substances have been shown to inhibit the deposition or to hasten the removal of excessive amounts of liver fat and to prevent kidney damage. Dimethylpropiothetin, the one most recently discovered (3, 4), was found in the marine alga Polysiphoniu jastigiata, but is not know...
متن کاملSYNTHESIS AND DETERMINATION OF THE LIPOTROPIC ACTIVITY OF THE BETAINE HYDROCHLORIDES OF dl-SERINE, GTHREONINE, AND dl-ALLOTHREONINE*
This paper reports the synthesis of the betaine hydrochlorides of serine, threonine, and allothreonine and a study of the action of these substances on the lipid content of the livers of rats fed a high fat, low protein diet. This work was undertaken for two purposes. Best and Huntsman (1) found that choline prevented the development of fatty livers in rats fed a high fat diet and that betaine ...
متن کاملSYNTHESIS AND DETERMINATION OF THE LIPOTROPIC ACTIVITY OF THE BETAINE HYDROCHLORIDES OF dl-SERINE, GTHREONINE, AND dl-ALLOTHREONINE*
This paper reports the synthesis of the betaine hydrochlorides of serine, threonine, and allothreonine and a study of the action of these substances on the lipid content of the livers of rats fed a high fat, low protein diet. This work was undertaken for two purposes. Best and Huntsman (1) found that choline prevented the development of fatty livers in rats fed a high fat diet and that betaine ...
متن کاملThe Effect of Dietary Fat on the Lipotropic Action of Inositol
The possibility that choline exerts lipotropic action through its introduction into newly formed lecithin molecules is an attractive hypothesis for which there exists some supporting evidence (l-3). Inositol, which is also a constituent of phospholipid (4, 5), may possibly exert its effect in the same way. McHenry and Patterson (6) have already suggested this possibility. If these two substance...
متن کاملL-carnitine alleviates alcohol-induced liver damage in rats: role of tumour necrosis factor-alpha.
AIMS Excessive alcohol intake induces hepatic fatty infiltration, which has been suggested to sensitize the liver to further damage. To test this hypothesis, L-carnitine, a constitutional lipotropic compound, was administered to rats chronically treated with ethanol by liquid diet feeding for 10 weeks. RESULTS Ethanol administration caused marked steatosis, mild inflammation and elevated plas...
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 14 شماره
صفحات -
تاریخ انتشار 1942