Lipotropic Substances *

نویسنده

  • Elizabeth G. Frame
چکیده

Lipotropic action of choline In 1924 Allan, Bowie, Macleod, and Robinson' reported that depancreatized dogs receiving adequate amounts of insulin and maintained on a diet of lean meat, sucrose, and bone ash did not survive for periods of longer than a few months. They also observed that symptoms of failure of liver function due to fat infiltration of the liver found in such animals could be prevented by adding raw pancreas to the diet. They suggested, therefore, that the pancreas might possibly produce an internal secretion necessary for the physiological integrity of the liver. In 1930 and 1931 Hershey56 and Hershey and Soskin57 found that crude egg-yolk lecithin could successfully replace raw pancreas in the diet of the depancreatized dog. Attention was temporarily withdrawn from the study of the fatty liver of the depancreatized dog by the discovery by Best et al."3 that the development of fatty livers in rats fed on a high fat diet could be prevented by the addition of lecithin to the diet. The application of this relatively simple type of experiment, that is, the use of rats fed on a diet of mixed grain and containing 40% beef fat, in place of the use of the depancreatized dog, led to rapid progress in the field. The first step in the development was made by Best and Huntsman"4 when they found that choline was the active agent in lecithin which prevented the accumulation of liver fat. Subsequent work by Best, Channon, and Ridout" on fractionation of the liver fat revealed that the fatty liver caused by feeding diets high in fat was occasioned entirely by an increase in the neutral fat fraction with no effect on the cholesterol or phospholipid fractions, and they also obtained confirmation of the action of choline in preventing such

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عنوان ژورنال:
  • The Yale Journal of Biology and Medicine

دوره 14  شماره 

صفحات  -

تاریخ انتشار 1942